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Across lifespan, in health and disease states, the cells that make up the brain undergoes changes - neuronal and cellular degenerations, consequently affecting their functions. Research activities being developed in the DELSU Joint Canada-Israel Neuroscience and Biopsychiatry Lab headed by Dr. Ben-Azu Benneth as Principal Investigator, aims to elucidate how multiple epigenetic factors such stress, diets, infections, and drug abuse affect brain immunity in health and neuropsychiatric states. Our ultimate goal is to design novel therapeutic strategies that specifically target markers of neurochemical changes, oxidative stress, neurotrophism, apoptosis, cellular senescence, and neuroinflammation, including microglia dysfunction, to prevent and treat major neurodevelopmental and neurodegenerative diseases such as schizophrenia, autism, attention deficit hyperactive disease, anxiety- and major depressive disorders, Alzheimer’s and Parkinson's diseases.
Investigating the impacts of epigenetic factors such as diets, stress, addiction, infection and pollution on brain immunity and their role in neuropsychiatric conditions, with a focus to understand the molecular mechanisms underlying neuroinflammation and its contributions to diseases.
Studying the role of neurotrophic factors in promoting neuronal survival and functions, with particular emphasis on their potential as targets for interventions in conditions such as schizophrenia, autism, Alzheimer’s and Parkinson’s diseases.
Investigating neurochemical alterations associated with depression, anxiety disorders and other neuropsychiatric conditions to identify potential targets for novel therapeutic interventions aimed at alleviating symptoms and improving mental health outcomes.
Understanding the impacts of neuroinflammation on brain functions, neuropsychiatric and neurodegenerative diseases, with a focus on elucidating the role of immune responses, notably microglia function, in modulating neuronal activities and their implications for cognitive and emotional well-being.
Investigating the mechanisms of cellular senescence in health and disease states across different age trajectories, with interests in their potential as targets for the development senolytics for interventions in conditions such Alzheimer's disease.