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Across lifespan, in health and disease states, the cells that make up the brain undergoes changes - neuronal and cellular degenerations, consequently affecting their functions. Research activities being developed in the DELSU Joint Canada-Israel Neuroscience and Biopsychiatry Lab headed by Dr. Ben-Azu Benneth as Principal Investigator, aims to elucidate how multiple epigenetic factors such as stress, diets, infections, and drug abuse affect brain immunity in health and neuropsychiatric states. Our ultimate goal is to design novel therapeutic strategies that specifically target markers of neurochemical changes, oxidative stress, neurotrophism, apoptosis, cellular senescence, and neuroinflammation, including microglia dysfunction, to prevent and treat major neurodevelopmental and neurodegenerative diseases such as schizophrenia, autism, attention deficit hyperactive disease, anxiety- and major depressive disorders, Alzheimer’s and Parkinson's diseases.
The Delta State University (DELSU) Joint Canada-Israel Neuroscience and Biopsychiatry Laboratory, established with the approval of the Vice Chancellor Prof. Egwunyenga O. Andy, is domiciled at the Department of Pharmacology, Faculty of Basic Medical Sciences, College of Health Sciences, Campus 3, Delta State University, Abraka. The laboratory was approved following the successful award of the Joint Canada-Israel Health Research Project in 2022. Our primary research focus encompasses neuroscience-based experiments, including behavioural studies and biochemical and molecular assays. However, the laboratory is equipped to undertake a wide range of research methodologies. Our investigations at the DELSU Joint Canada-Israel Neuroscience and Biopsychiatry Laboratory aim to elucidate the impact of epigenetic factors on brain development in health and disease states. Specifically, we are elucidating how neuronal and cellular changes and neuroinflammatory-related mechanisms, notably changes in microglia functions, impact development, aging, and disease states, particularly in the context of neuropsychiatric conditions. In line with this, we are always seeking to improve our technical skill sets.
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